DREADD agonist 21

Cat. No. 5548

DREADD agonist 21 C17H18N4 [56296-18-5]

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Chemical Name: 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Biological Activity

Potent muscarinic hM3Dq DREADD agonist (EC50 = 1.7 nM). Highly selective for hM3Dq DREADDs over endogenous hM3 receptors.

Technical Data

M.Wt:
278.35
Formula:
C17H18N4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
56296-18-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chen et al (2015) The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 18 476. PMID: 25587888.

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Keywords: DREADD agonist 21, supplier, designer, receptors, drugs, DREADDs, hM3Dq, muscarinic, receptors, Tocris Bioscience, DREADD Ligand Activator products

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