Cat. No. 5547
Chemical Name: 5-Methyl-N-[2-(1-piperidinyl)phenyl
Biological ActivityTRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Chen et al (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 5 4681. PMID: 25119295.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses MK6-83 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MK6-83, supplier, TRPML, transient, receptor, potential, channels, activators, activates, mucolipidosis, MLIV, Tocris Bioscience, TRPML Activator products
Find multiple products by catalog number
New Products in this Area
Potent TRPV1 antagonistPF 05105679
Selective TRPM8 blockerM 084 hydrochloride
TRPC4/5 channel blocker; antidepressant and anxiolyticA 425619
Potent TRPV1 antagonist
December 13 - 15, 2016