Cat. No. 5547
Chemical Name: 5-Methyl-N-[2-(1-piperidinyl)phenyl
Biological ActivityTRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Chen et al (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 5 4681. PMID: 25119295.
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Keywords: MK6-83, supplier, TRPML, transient, receptor, potential, channels, activators, activates, mucolipidosis, MLIV, Tocris Bioscience, TRPML Activator products