Cat. No. 5546
Chemical Name: 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-d
Biological ActivityPotent and selective BRPF bromodomain inhibitor (Kd values are 31, 108 and 408 nM, for BRPF1B, 2 and 3, respectively. Exhibits >32-fold selectivity for BRPFs over BRD9 and other non-Class IV bromodomains.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NI 57 probe summary on the SGC website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
If you know of a relevant reference for NI 57 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NI 57 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: NI 57, supplier, NI57, potent, and, selective, bromodomain, inhibitors, inhibits, BRPF, sgc, structural, genomics, consortium, Tocris Bioscience, Bromodomain Inhibitor products
Find multiple products by catalog number
New Products in this Area
High affinity BET bromodomain ligandTP 472N
Negative control for TP 472 (Cat. No. 6000).TP 472
Potent BRD9/7 inhibitorBAY 299
Potent and selective BRD1 and TAF1 inhibitor
Tocris has a collaboration with the Structural Genomics Consortium (SGC) to provide the latest high quality epigenetics probes.