Cat. No. 5545
Chemical Name: N-[2,6-Dibromo-4-(1-methylethyl)phe
Biological ActivitySelective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ase et al (2015) Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels Mol.Pharmacol. 87 606. PMID: 25597706.
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Keywords: BX 430, supplier, BX430, selective, allosteric, noncompetitive, antagonists, antaognism, purinergic, receptors, purinoceptors, P2X4, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products