(S)-SNAP 5114

Cat. No. 1561

(S)-SNAP 5114 C30H35NO6 [157604-55-2]

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Chemical Name: 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid

Biological Activity

GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.

Technical Data

M.Wt:
505.61
Formula:
C30H35NO6
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
157604-55-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Dalby (2000) GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 39 2399. PMID: 10974324.

Borden (1996) GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem.Int. 29 335. PMID: 8939442.

Borden et al (1994) Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 2 207. PMID: 7874447.

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Keywords: (S)-SNAP 5114, supplier, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT-2, GAT-3, Transporters, Monoamine, Neurotransmitter, (S)-SNAP5114, Tocris Bioscience, GABA Inhibitor products

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