Cat. No. 1561
Chemical Name: 1-[2-[tris(4-methoxyphenyl)methoxy]
Biological ActivityGABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Dalby (2000) GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 39 2399. PMID: 10974324.
Borden (1996) GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem.Int. 29 335. PMID: 8939442.
Borden et al (1994) Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 2 207. PMID: 7874447.
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Citations are publications that use Tocris products. Selected citations for (S)-SNAP 5114 include:
Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Physiol 36 607. PMID: 26758848.
Kékesi et al (2015) Recurrent seizure-like events are associated with coupled astroglial synchronization. J Neurosci 9 215. PMID: 26150770.
Kersanté et al (2013) A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. J Neurophysiol 591 2429. PMID: 23381899.
Kinney (2005) GAT-3 transporters regulate inhibition in the neocortex. Mol Pain 94 4533. PMID: 16135550.
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Keywords: (S)-SNAP 5114, supplier, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT-2, GAT-3, Transporters, Monoamine, Neurotransmitter, (S)-SNAP5114, Tocris Bioscience, GABA Inhibitor products
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