Cat. No. 5524
Chemical Name: 8-[(4-Chlorophenyl)thio]-guanosine-
Biological ActivityPKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kim et al (2015) Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 112 3122. PMID: 25713349.
Poppe et al (2008) Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 5 277. PMID: 18376388.
Gamm et al (1995) The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 270 27380. PMID: 7593002.
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Keywords: Rp-8-pCPT-cGMPS sodium, supplier, PKG, cGMP-dependent, kinases, PKGIbeta, PKGIb, PKGIμ, PKGIalpha, PKGIa, PKGIα, PKGII, LTP, potentiation, long, term, Tocris Bioscience, Protein Kinase G Inhibitor products
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