Cat. No. 5522
Chemical Name: 2-Acetylnaphtho[2,3-b]furan-4,9-dio
Biological ActivitySTAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Li et al (2015) Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc.Natl.Acad.Sci.USA. 112 1839. PMID: 25605917.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Napabucasin from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Napabucasin, supplier, Stat3, inhibitors, inhibits, cancer, stem, cell, stemness, high, self-renewal, spherogenesis, metastasis, Tocris Bioscience, STAT Inhibitor products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.