Cat. No. 5522
Chemical Name: 2-Acetylnaphtho[2,3-b]furan-4,9-dio
Biological ActivitySTAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Li et al (2015) Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc.Natl.Acad.Sci.USA. 112 1839. PMID: 25605917.
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Keywords: Napabucasin, supplier, Stat3, inhibitors, inhibits, cancer, stem, cell, stemness, high, self-renewal, spherogenesis, metastasis, Tocris Bioscience, STAT Inhibitor products