Isotretinoin

Cat. No. 5513

Isotretinoin C20H28O2 [4759-48-2]

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Alternative Names: 13-cis-retinoic acid, Accutane

Chemical Name: 13-cis-Retinoic acid

Biological Activity

Endogenous agonist for retinoic acid receptors. Promotes neurite outgrowth, cell differentiation and inhibits proliferation in a neuroblastoma cell line. Also increases protein expression levels of MYCN and retinoic acid receptor-β. Anti-inflammatory.

Technical Data

M.Wt:
300.44
Formula:
C20H28O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
4759-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Sonawane et al (2014) Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma. Br.J.Pharmacol. 171 5330. PMID: 25039756.

Diamandis et al (2007) Chemical genetics reveals a complex functional ground state of neural stem cells. Nat.Chem.Biol. 3 268. PMID: 17417631.

Blaner et al (2001) Cellular metabolism and actions of 13-cis-retinoic acid. J.Am.Acad.Dermatol. 45 S129. PMID: 11606944.

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Keywords: Isotretinoin, supplier, Endogenous, agonists, retinoic, acid, receptors, neuronal, differentiation, anti-inflammatory, RAR, Retinoic, Acid, Receptors, RXR, Retinoid, X, Tocris Bioscience, Retinoic Acid Receptor Agonist products

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