Cat. No. 5513
Alternative Names: 13-cis-retinoic acid, Accutane
Chemical Name: 13-cis-Retinoic acid
Biological ActivityEndogenous agonist for retinoic acid receptors. Promotes neurite outgrowth, cell differentiation and inhibits proliferation in a neuroblastoma cell line. Also increases protein expression levels of MYCN and retinoic acid receptor-β. Anti-inflammatory.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Sonawane et al (2014) Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma. Br.J.Pharmacol. 171 5330. PMID: 25039756.
Diamandis et al (2007) Chemical genetics reveals a complex functional ground state of neural stem cells. Nat.Chem.Biol. 3 268. PMID: 17417631.
Blaner et al (2001) Cellular metabolism and actions of 13-cis-retinoic acid. J.Am.Acad.Dermatol. 45 S129. PMID: 11606944.
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Keywords: Isotretinoin, supplier, Endogenous, agonists, retinoic, acid, receptors, neuronal, differentiation, anti-inflammatory, RAR, Retinoic, Acid, Receptors, RXR, Retinoid, X, Tocris Bioscience, Retinoic Acid Receptor Agonist products
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