AP 811

Cat. No. 5498

AP 811 N2-[4-(2-Naphthoylamino)phenylacetyl]-Arg-Ile-Asp-Arg-(S)-2-methylbutylamide

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Biological Activity

High affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.

Technical Data

M.Wt:
915.1
Formula:
C46H66N12O8
Sequence:
RIDR

(Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
124833-45-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Becker et al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335. PMID: 24353062.

William et al (2008) Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am.J.Physiol.Cell Physiol. 294 C1067. PMID: 18272821.

Veale et al (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg.Med.Chem.Lett. 10 1949. PMID: 10987424.

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Keywords: AP 811, supplier, AP811, NPR3, ANP-CR, atrial, natriuretic, peptides, clearance, receptor, antagonists, antagonism, selective, high, affinity, Tocris Bioscience, Natriuretic Peptide Receptor Antagonist products

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