XL 413 hydrochloride

Cat. No. 5493

XL 413 hydrochloride C14H12ClN3O2.HCl [1169562-71-3]

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Alternative Name: BMS 863233

Chemical Name: 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride

Biological Activity

Potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice.

Technical Data

M.Wt:
326.18
Formula:
C14H12ClN3O2.HCl
Solubility:
Soluble to 20 mM in water
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
1169562-71-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sasi et al (2014) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS ONE 9 e113300. PMID: 25412417.

Koltun et al (2012) Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg.Med.Chem.Lett. 22 3727. PMID: 22560567.

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Keywords: XL 413 hydrochloride, supplier, XL413, hydrochloride, BMS863233, potent, selective, inhibits, inhibitors, cdc7, cell, division, cycle, kinases, Tocris Bioscience, Other Kinase Inhibitor products

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