Cat. No. 5492
Chemical Name: N-[1-[6-(4-Ethyl-1-piperazinyl)-3-p
Biological ActivityPotent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Watterson et al (2007) Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 50 3730. PMID: 17585753.
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Keywords: BMS 566419, supplier, BMS566419, inosine, monophosphate, dehydrogenase, inhibitors, inhibits, IMPDH, immunosuppressant, anti-inflammatory, rheumatoid, arthritis, orally, available, potent, Tocris Bioscience, Other Dehydrogenase Inhibitor products
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