BMS 566419

Cat. No. 5492

BMS 566419 C28H30FN5O2 [566161-24-8]

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Chemical Name: N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide

Biological Activity

Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.

Technical Data

Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Watterson et al (2007) Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 50 3730. PMID: 17585753.

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Keywords: BMS 566419, supplier, BMS566419, inosine, monophosphate, dehydrogenase, inhibitors, inhibits, IMPDH, immunosuppressant, anti-inflammatory, rheumatoid, arthritis, orally, available, potent, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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