Cat. No. 5491
Alternative Name: SPP 100
Chemical Name: (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dim
Biological ActivityPotent renin inhibitor (IC50 = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kaye and Krum (2007) Drug discovery for heart failure: a new era or the end of the pipeline? Nat.Rev.Drug Discov. 6 127. PMID: 17268484.
Jensen et al (2) Aliskiren: the first renin inhibitor for clinical treatment. Nat.Rev.Drug Discov. 7 399. PMID: 18340340.
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Citations are publications that use Tocris products.
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Keywords: Aliskiren hemifumarate, supplier, SPP100, Potent, renin, inhibitors, inhibits, hypertensive, hypertension, blood, pressure, heart, Tocris Bioscience, Other Protease Inhibitor products
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