Aliskiren hemifumarate

Cat. No. 5491

Aliskiren hemifumarate C30H53N3O6.1/2C4H4O4 [173334-58-2]

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Alternative Name: SPP 100

Chemical Name: (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumarate

Biological Activity

Potent renin inhibitor (IC50 = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kaye and Krum (2007) Drug discovery for heart failure: a new era or the end of the pipeline? Nat.Rev.Drug Discov. 6 127. PMID: 17268484.

Jensen et al (2) Aliskiren: the first renin inhibitor for clinical treatment. Nat.Rev.Drug Discov. 7 399. PMID: 18340340.

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Keywords: Aliskiren hemifumarate, supplier, SPP100, Potent, renin, inhibitors, inhibits, hypertensive, hypertension, blood, pressure, heart, Tocris Bioscience, Other Protease Inhibitor products

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