Tracazolate hydrochloride

Cat. No. 1558

Tracazolate hydrochloride C16H24N4O2.HCl [1135210-68-2]

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Alternative Name: ICI 136753

Chemical Name: 4-(Butylamino)-1-ethyl-6-methyl 1H-pyrazolo[3,4b]pyridine-5-ethylcarboxylate hydrochloride

Biological Activity

Subtype-selective GABAA receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Enhances native GABAA receptor function and is anxiolytic following systemic administration in vivo.

Technical Data

M.Wt:
340.85
Formula:
C16H24N4O2.HCl
Solubility:
Soluble to 100 mM in 1eq. HCl
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1135210-68-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Thompson et al (2002) Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acidA receptors. Mol.Pharmacol. 61 861. PMID: 11901225.

Meiners and Salama (1982) Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate. Eur.J.Pharmacol. 78 315. PMID: 6121710.

Patel and Malick (1982) Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur.J.Pharmacol. 78 323. PMID: 6121711.

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Keywords: Tracazolate hydrochloride, supplier, Subtype-selective, GABAA, allosteric, modulators, Receptors, ICI136753, Tocris Bioscience, GABAA Receptor Modulator products

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