Cat. No. 1558
Alternative Name: ICI 136753
Chemical Name: 4-(Butylamino)-1-ethyl-6-methyl 1H-pyrazolo[3,4b]pyridine-5-ethylca
Biological ActivitySubtype-selective GABAA receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Enhances native GABAA receptor function and is anxiolytic following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Thompson et al (2002) Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acidA receptors. Mol.Pharmacol. 61 861. PMID: 11901225.
Meiners and Salama (1982) Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate. Eur.J.Pharmacol. 78 315. PMID: 6121710.
Patel and Malick (1982) Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur.J.Pharmacol. 78 323. PMID: 6121711.
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Citations are publications that use Tocris products. Selected citations for Tracazolate hydrochloride include:
Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Neurosci 34 10219. PMID: 25080584.
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Keywords: Tracazolate hydrochloride, supplier, Subtype-selective, GABAA, allosteric, modulators, Receptors, ICI136753, Tocris Bioscience, GABAA Receptor Modulator products