Cat. No. 5490
Chemical Name: N-[[(6-Hydroxy-1-naphthalenyl)amino
Biological ActivityCalcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kim et al (2014) Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J.Immunol. 192 110. PMID: 24307733 .
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Keywords: 5J 4, supplier, 5J4, CRAC, calcium, release, activated, store, operated, entry, SOCE, anti-inflammatory, channels, Ca2+, blockers, Tocris Bioscience, Other Calcium Channel Blocker products
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October 30 - November 3, 2016
Boston, MA, USA