5J 4

Cat. No. 5490

5J 4 C16H12N2O3S [827001-82-1]

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Chemical Name: N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide

Biological Activity

Calcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kim et al (2014) Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J.Immunol. 192 110. PMID: 24307733 .

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Keywords: 5J 4, supplier, 5J4, CRAC, calcium, release, activated, store, operated, entry, SOCE, anti-inflammatory, channels, Ca2+, blockers, Tocris Bioscience, Other Calcium Channel Blocker products

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