BML 111

Cat. No. 5488new

BML 111 C8H16O5 [78606-80-1]

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Chemical Name: (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate

Biological Activity

FPR2 (lipoxin A4 receptor) agonist. Suppresses tumor-related angiogenesis and reduces tumor growth in hepatoma H22 cell bearing mice. Also protects against hemorrhagic shock-induced acute lung injury in rats. Lipoxin A4 analog.

Technical Data

M.Wt:
192.21
Formula:
C8H16O5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
78606-80-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gong et al (2012) BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats. Resuscitation. 83 907. PMID: 22245750.

Chen et al (2010) Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. Mol.Cancer.Ther. 9 2164. PMID: 20682645.

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Keywords: BML 111, supplier, BML111, formyl, peptide, receptors, FPR2, agonists, agonism, lipoxinA4, LPA4, Tocris Bioscience, Formyl Peptide Receptor Agonist products

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