GlyH 101

Cat. No. 5485

GlyH 101 C19H15Br2N3O3 [328541-79-3]

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Chemical Name: N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide

Biological Activity

Reversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.

Technical Data

M.Wt:
493.15
Formula:
C19H15Br2N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
328541-79-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Norimatsu et al (2012) Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol.Pharmacol. 82 1042. PMID: 22923500.

Muanprasat et al (2004) Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J.Gen.Physiol. 124 125. PMID: 15277574.

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Keywords: GlyH 101, supplier, GlyH101, Cl-, chloride, channels, blockers, CFTR, cystic, fibrosis, transmembrane, conductance, regulators, voltage, dependent, Tocris Bioscience, CFTR Blocker products

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