TDFA

Cat. No. 5482

TDFA Ac-Thr-Asp-[N5-(2-fluoro-1-iminoethyl)]-Orn-NH2

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Biological Activity

Protein arginine deiminase 4 (PAD4) inhibitor (IC50 values are 2.3, 8.5, 26 and 71 μM for PAD4, PAD1, PAD3 and PAD2, respectively).

Technical Data

M.Wt:
448.45
Formula:
C17H29FN6O7
Sequence:
Ac-TD-X

(Modifications: Thr-1 = N-terminal Ac, X = N5-(2-fluoro-1-iminoethyl)]-Orn), X-3= C-terminal amide)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1345019-64-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jones et al (2012) Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem.Biol. 7 160. PMID: 22004374.

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Citations are publications that use Tocris products.

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Keywords: TDFA, supplier, PAD4, protein, arginine, deiminase, 4, inhibits, inhibitors, Tocris Bioscience, Post-Translational Modification Inhibitor products

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