Cat. No. 5482

TDFA Ac-Thr-Asp-[N5-(2-fluoro-1-iminoethyl)]-Orn-NH2

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Biological Activity

Protein arginine deiminase 4 (PAD4) inhibitor (IC50 values are 2.3, 8.5, 26 and 71 μM for PAD4, PAD1, PAD3 and PAD2, respectively).

Technical Data


(Modifications: Thr-1 = N-terminal Ac, X = N5-(2-fluoro-1-iminoethyl)]-Orn), X-3= C-terminal amide)

Soluble to 2 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Jones et al (2012) Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem.Biol. 7 160. PMID: 22004374.

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Keywords: TDFA, supplier, PAD4, protein, arginine, deiminase, 4, inhibits, inhibitors, Tocris Bioscience, Post-Translational Modification Inhibitor products

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