Cat. No. 5480

KRIBB11 C13H12N6O2 [342639-96-7]

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Chemical Name: N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine

Biological Activity

Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Samarasinghe et al (2014) Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem. Pharmacol. 87 445. PMID: 24291777.

Yoon et al (2011) KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J.Biol.Chem. 286 1737. PMID: 21078672.

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Citations are publications that use Tocris products.

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Keywords: KRIBB11, supplier, HSF1, inhibitors, inhibits, heat, shock, factors, 1, HSP90, HSP70, HSP27, proteins, Tocris Bioscience, Hsp90 products

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