CRID3 sodium salt

Cat. No. 5479

CRID3 sodium salt C20H23N2NaO5S [256373-96-3]

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Alternative Names: CP-456773, MCC 950

Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt

Biological Activity

Potent NLRP3 inflammasome inhibitor; inhibits IL-1β (IC50 = 7.2 nM), IL-1α (IC50 = 12-18 nM) and IL-18 (IC50 = 10.3 nM) production. Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Inhibits inflammasome activation by soluble and crystalline NLRP3 stimuli. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Technical Data

M.Wt:
426.46
Formula:
C20H23N2NaO5S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
256373-96-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Coll et al (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat.Med. 21 248. PMID: 25686105.

Laliberte et al (2003) Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing. J.Biol.Chem. 278 16567. PMID: 12624100.

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Keywords: CRID3 sodium salt, supplier, CP456773, cytokine, release, inhibitory, drug, CRID3, Glutathione, S-transferase, omega, 1, GSTO1, inhibitors, inhibits, MCC950, nod-like, receptors, NLRP3, inflammasome, Tocris Bioscience, Cytokine products

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