CRID3 sodium salt

Cat. No. 5479

CRID3 sodium salt C20H23N2NaO5S [256373-96-3]

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Alternative Names: CP-456773, MCC 950

Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt

Biological Activity

Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production (IC50 = 7.5 nm). Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>97 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Coll et al (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat.Med. 21 248. PMID: 25686105.

Coll et al (2011) The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS ONE 6 e29539. PMID: 22216309.

Laliberte et al (2003) Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing. J.Biol.Chem. 278 16567. PMID: 12624100.

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Keywords: CRID3 sodium salt, supplier, CP456773, cytokine, release, inhibitory, drug, CRID3, Glutathione, S-transferase, omega, 1, GSTO1, inhibitors, inhibits, MCC950, nod-like, receptors, NLRP3, inflammasome, Tocris Bioscience, Cytokine products

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