Cytochalasin B

Cat. No. 5474

Cytochalasin B C29H37NO5 [14930-96-2]

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Chemical Name: (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione

Biological Activity

Inhibitor of actin polymerization. Inhibits cell division, migration and glucose transport. Causes G2/M cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma cells. Cell permeable.

Technical Data

M.Wt:
479.61
Formula:
C29H37NO5
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
14930-96-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Buldak et al (2014) Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment. Eur.J.Histochem. 58 2408. PMID: 25308845.

Whitesell et al (2005) Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line. Biochem.J. 386 245. PMID: 15473866.

Theodoropoulos et al (1994) Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochem.Pharmacol. 47 1875. PMID: 8204105.

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Keywords: Cytochalasin B, supplier, inhibitors, inhibits, actin, polymerization, polymerisation, cell, permeable, division, migration, cell, cycle, arrest, cytokinesis, Tocris Bioscience, Actin Inhibitor products

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