CGP 74514 dihydrochloride

Cat. No. 5472

CGP 74514 dihydrochloride C19H24ClN7.2HCl

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Chemical Name: rel-N2-[(1R,2S)-2-Aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine dihydrochloride

Biological Activity

Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.

Technical Data

Soluble to 50 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Yu et al (2013) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res. 63 1822. PMID: 12702569.

Furet et al (2000) Structure-based design of potent CDK1 inhibitors derived from olomoucine. J.Comput.Aided Mol.Des. 14 403. PMID: 10896313.

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Keywords: CGP 74514 dihydrochloride, supplier, CGP74514, dihydrochloride, cyclin, dependent, kinase, inhibitors, inhibits, CDK1, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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