QAQ dichloride

Cat. No. 5470

QAQ dichloride C28H44Cl2N6O2

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Chemical Name: 2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride

Biological Activity

Photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.

Technical Data

M.Wt:
567.59
Formula:
C28H44Cl2N6O2
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mourot et al (2012) Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 9 396. PMID: 22343342.

Banghart MR et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097. PMID: 19882609.

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Keywords: QAQ dichloride, supplier, photoswitchable, Kv, potassium, channels, K+, blockers, Ca2+, Cav, calcium, Na+, Nav, sodium, local, anesthesia, anesthetic, ligands, Tocris Bioscience, Photoswitchable Ligand products

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