6'-Iodoresiniferatoxin

Cat. No. 1556

6'-Iodoresiniferatoxin C37H39IO9 [335151-55-8]

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Alternative Name: 6'-IRTX

Chemical Name: [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]-4-hydroxy-2-iodo-5-methoxy-benzeneacetic acid methyl ester

Biological Activity

High affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1). Displays partial agonism at human VR1 and full agonism at rat VR1.

Technical Data

M.Wt:
754.6
Formula:
C37H39IO9
Solubility:
Soluble in ethanol and in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
335151-55-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

McDonnell et al (2002) Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor. Bioorg.Med.Chem.Lett. 12 1189. PMID: 11934585.

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Keywords: 6'-Iodoresiniferatoxin, supplier, High, affinity, TRPV1, agonists, partial, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, 6-Iodoresiniferatoxin, 6-IRTX, Tocris Bioscience, TRPV Agonist products

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