AC 4

Cat. No. 5464new

AC 4 C26H25F3N4O2S [1459809-09-6]

Price and Availability

For AC 4 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1,3,4,5-Tetrahydro-7,8-dihydro-N-[2-[4-[2-[4-(trifluoromethyl)phenyl]diazenyl]phenyl]ethyl]-2H-2-benzazepine-2-carbothioamide

Biological Activity

Photoswitchable TRPV1 channel blocker (IC50 = 3.1 μM). Acts as an antagonist in trans conformation during voltage gated activation. Also acts as an antagonist in the cis formation during capsaicin-induced TRPV1 currents. Switches conformation from cis to trans at 440 nm and trans to cis at 360 nm. Allows photoswitchable antagonist and an agonist to be applied at the same time.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Stein et al (2013) Optical control of TRPV1 channels. Angew.Chem.Int.Ed.Engl. 52 9845. PMID: 23873837.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses AC 4 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: AC 4, supplier, Photoswitchable, TRPV1, channel, blockers, transient, receptor, potential, vanilloids, ligands, Tocris Bioscience, Photoswitchable Ligand products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Spring/Summer 2016)

Our New Product guide highlights over 110 new products added in the first half of 2016. View PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.