Cat. No. 5464
Chemical Name: 1,3,4,5-Tetrahydro-7,8-dihydro-N-[2
Biological ActivityPhotoswitchable TRPV1 channel blocker (IC50 = 3.1 μM). Acts as an antagonist in trans conformation during voltage gated activation. Also acts as an antagonist in the cis formation during capsaicin-induced TRPV1 currents. Switches conformation from cis to trans at 440 nm and trans to cis at 360 nm. Allows photoswitchable antagonist and an agonist to be applied at the same time.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Stein et al (2013) Optical control of TRPV1 channels. Angew.Chem.Int.Ed.Engl. 52 9845. PMID: 23873837.
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Keywords: AC 4, supplier, Photoswitchable, TRPV1, channel, blockers, transient, receptor, potential, vanilloids, ligands, Tocris Bioscience, Photoswitchable Ligand products
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August 20 - 24, 2017
Paris , France