PA 1 dihydrochloride

Cat. No. 5463

PA 1 dihydrochloride C18H16ClN9O.2HCl

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Chemical Name: 3,5-Diamino-6-chloro-N-[imino[[4-(2-phenyldiazenyl)phenyl]amino]methyl]-2-pyrazinecarboxamide dihydrochloride

Biological Activity

Photoswitchable epithelial sodium channel (ENaC) blocker (IC50 values are 90 and 390 nM for αβγ and δβγENaCs, respectively, in the trans conformation). Switches conformation from cis to trans at 500 nm and trans to cis at 400 nm. Blocks ENaCs with greater efficacy in the cis conformation, in comparison to the trans conformation, in Xenopus oocytes and HEK293t cells. Partially blocks δβγENaCs in the trans conformation and exhibits near maximal block of δβγENaCs in the cis conformation. Amiloride derivative.

Technical Data

M.Wt:
482.75
Formula:
C18H16ClN9O.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Schönberger et al (2014) Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat.Chem. 6 712. PMID: 25054942.

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Keywords: PA 1 dihydrochloride, supplier, photoswitchable, ENaC, blockers, epithelial, sodium, channels, Na+, photoamiloride-1, PA1, ligands, Tocris Bioscience, Photoswitchable Ligand products

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