AAQ chloride

Cat. No. 5462

AAQ chloride C23H30ClN5O2

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Chemical Name: N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminium chloride

Biological Activity

Photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.

Licensing Information

Sold under license from Photoswitch Biosciences, Inc.

Technical Data

Soluble to 20 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Polosukhina et al (2012) Photochemical restoration of visual responses in blind mice. Neuron 75 271. PMID: 22841312.

Banghart et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097. PMID: 19882609.

Fortin et al (2008) Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 5 331. PMID: 18311146.

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Keywords: AAQ chloride, supplier, selective, photoswitchable, Kv, potassium, channels, K+, blockers, ligands, Tocris Bioscience, Photoswitchable Ligand products

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