Cat. No. 5460
Chemical Name: 5-[3-Bromo-4-(dimethylamino)phenyl]
Biological ActivityAllosteric inhibitor of glutaminase. Blocks Rho-GTPase-dependent transformation of fibroblasts. Suppresses breast cancer cell growth and invasive activity in vitro. Also inhibits P-493 B lymphoma cell growth and reduces tumor size of P-493 cell xenografts in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Stalnecker et al (2015) Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 112 394. PMID: 25548170.
Lu et al (2010) Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell 18 199. PMID: 20832746.
Wang et al (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18 207. PMID: 20832749.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses 968 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 968, supplier, Hydrolases, allosteric, inhibitors, inhibits, glutaminase, oncogene, transformation, gls1, Tocris Bioscience, Glutaminase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeableJZP 361
Potent and selective reversible MAGL inhibitorURB 602
Non-competitive MAGL inhibitor(S)-Crizotinib
Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrantJZP 430
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.