Cytosporone B

Cat. No. 5459

Cytosporone B C18H26O5 [321661-62-5]

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Chemical Name: Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate

Biological Activity

Naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.

Technical Data

M.Wt:
322.4
Formula:
C18H26O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
321661-62-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Palumbo-Zerr et al (2015) Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 21 150. PMID: 25581517.

Zhan et al (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 4 548. PMID: 18690216.

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Citations are publications that use Tocris products.

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Keywords: Cytosporone B, supplier, naturally, occurring, high, affinity, Nur77, NR4A1, agonists, agonism, TR3, NGFI-B, TIS1, NAK-1, apoptosis, blood, glucose, antifibrotic, fibrosis, Tocris Bioscience, Other Nuclear Receptor Agonist products

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