SirReal 2

Cat. No. 5457

SirReal 2 C22H20N4OS2 [709002-46-0]

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Chemical Name: 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide

Biological Activity

Selective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.

Technical Data

M.Wt:
420.55
Formula:
C22H20N4OS2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
709002-46-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rumpf et al (2015) Selective SIRT2 inhibition by ligand-induced rearrangement of the active site. Nat.Commun. 6 6263. PMID: 25672491.

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Keywords: SirReal 2, supplier, SirReal2, selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Tocris Bioscience, Sir 2-like Family Deacetylase Inhibitor products

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