Cat. No. 5457
Chemical Name: 2-[(4,6-Dimethyl-2-pyrimidinyl)thio
Biological ActivitySelective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Rumpf et al (2015) Selective SIRT2 inhibition by ligand-induced rearrangement of the active site. Nat.Commun. 6 6263. PMID: 25672491.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SirReal 2 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SirReal 2, supplier, SirReal2, selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Tocris Bioscience, Sir 2-like Family Deacetylase Inhibitor products
Find multiple products by catalog number
New Products in this Area
HDAC5 and HDAC9 inhibitorMC 1742
Potent class I and IIb HDAC inhibitorYK 3-237
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.