Zosuquidar trihydrochloride

Cat. No. 5456

Zosuquidar trihydrochloride C32H31F2N3O2.3HCl [167465-36-3]

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Alternative Name: LY 335979

Chemical Name: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride

Biological Activity

High affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

Technical Data

M.Wt:
636.99
Formula:
C32H31F2N3O2.3HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
167465-36-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Dantzig et al (1999) Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. J.Pharmacol.Exp.Ther. 290 854. PMID: 10411602.

Dantzig et al (1996) Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 56 4171. PMID: 8797588.

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Keywords: Zosuquidar trihydrochloride, supplier, LY335979, RS33295198, high, affinity, p-glycoprotein, p-gp, inhibitors, inhibits, multidrug, transporters, resistance, Tocris Bioscience, Multidrug Transporter Inhibitor products

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