Cat. No. 5456
Alternative Name: LY 335979
Chemical Name: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a
Biological ActivityHigh affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Dantzig et al (1999) Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. J.Pharmacol.Exp.Ther. 290 854. PMID: 10411602.
Dantzig et al (1996) Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 56 4171. PMID: 8797588.
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Keywords: Zosuquidar trihydrochloride, supplier, LY335979, RS33295198, high, affinity, p-glycoprotein, p-gp, inhibitors, inhibits, multidrug, transporters, resistance, Tocris Bioscience, Multidrug Transporter Inhibitor products
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