Cat. No. 5455
Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]
Biological ActivityHigh affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cho et al (2014) Autocrine effects of tumor-derived complement. Cell Rep. 6 1085. PMID: 24613353.
Monk et al (2007) Function, structure and therapeutic potential of complement C5a receptors. Br.J.Pharmacol. 152 429. PMID: 17603557.
Sumichika et al (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist. J.Biol.Chem. 277 49403. PMID: 12384495 .
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Citations are publications that use Tocris products.
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Keywords: W 54011, supplier, W54011, high, affinity, C5a, receptors, antagonists, antagonism, neutrophils, complement, Tocris Bioscience, Complement Antagonist products
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