W 54011

Cat. No. 5455

W 54011 C30H36N2O2.HCl [405098-33-1]

Price and Availability

For W 54011 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride

Biological Activity

High affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

Technical Data

M.Wt:
493.08
Formula:
C30H36N2O2.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
405098-33-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cho et al (2014) Autocrine effects of tumor-derived complement. Cell Rep. 6 1085. PMID: 24613353.

Monk et al (2007) Function, structure and therapeutic potential of complement C5a receptors. Br.J.Pharmacol. 152 429. PMID: 17603557.

Sumichika et al (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist. J.Biol.Chem. 277 49403. PMID: 12384495 .

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses W 54011 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: W 54011, supplier, W54011, high, affinity, C5a, receptors, antagonists, antagonism, neutrophils, complement, Tocris Bioscience, Complement Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

New Products in this Area

SAG 21k

Hedgehog signaling activator; brain penetrant and orally bioavailable

G10

Activator of STING-dependent signaling

3',3'-cGAMP sodium salt

STING agonist

2',3'-cGAMP sodium salt

Endogenous high affinity STING agonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.