W 54011

Cat. No. 5455

W 54011 C30H36N2O2.HCl [405098-33-1]

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Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride

Biological Activity

High affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

Technical Data

Soluble to 50 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cho et al (2014) Autocrine effects of tumor-derived complement. Cell Rep. 6 1085. PMID: 24613353.

Monk et al (2007) Function, structure and therapeutic potential of complement C5a receptors. Br.J.Pharmacol. 152 429. PMID: 17603557.

Sumichika et al (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist. J.Biol.Chem. 277 49403. PMID: 12384495 .

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Citations are publications that use Tocris products.

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Keywords: W 54011, supplier, W54011, high, affinity, C5a, receptors, antagonists, antagonism, neutrophils, complement, Tocris Bioscience, Complement Antagonist products

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