Cat. No. 5449

Erastin C30H31ClN4O4 [571203-78-6]

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Chemical Name: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone

Biological Activity

Antitumor agent; selective for cells expressing oncogenic RAS. Also Ferroptosis activator; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

Technical Data

Soluble to 20 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060. PMID: 22632970.

Yagoda et al (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 864. PMID: 17568748.

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285. PMID: 12676586.

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Keywords: Erastin, supplier, Synthetic, lethality, antitumor, agent, RAS-selective, lethal, synthetic, lethality, KRAS,, HRAS,, BRAF, small, T, ST, oncoprotiens, ferroptosis, activators, voltage-dependent, anion, channels, VDAC, Tocris Bioscience, Other Channel Modulator products

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