Cat. No. 5446
Chemical Name: 3-(3,4,5-Trihydroxybenzoyloxy)napht
Biological ActivityFASN inhibitor. Inhibits breast cancer cell proliferation in vitro (IC50 values are 21 - 79 μM), including cell lines resistant to anti-HER2 therapies. Blocks HER2 signaling and induces apoptosis. Inhibits growth of breast cancer xenografts in mice without causing anorexia.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Puig et al (2011) A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 13 R131. PMID: 22177475 .
Puig et al (2009) Novel inhibitors of fatty acid synthase with anticancer activity. Clin.Cancer Res. 15 7608. PMID: 20008854.
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Keywords: G 28UCM, supplier, G28UCM, fatty, acid, synthase, inhibitors, inhibits, FASN, breast, cancer, Tocris Bioscience, Fatty Acid Synthase Inhibitor products
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