Cat. No. 5443
Chemical Name: 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-
Biological ActivityHigh affinity and selective CB1 antagonist (Ki = 3.3 nM). Exhibits >100-fold selectivity for CB1 over CB2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Bowles et al (2015) A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proc.Natl.Acad.Sci.U.S.A. 112 285. PMID: 25535367.
Tam et al (2010) Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J.Clin.Invest. 120 2953. PMID: 20664173.
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Keywords: AM 6545, supplier, AM6545, CB1, receptors, antagonists, high, affinity, selective, obesity, lipids, glucose, Tocris Bioscience, CB1 Receptor Antagonist products