Cat. No. 2749
Alternative Name: d-Medetomidine hydrochloride
Chemical Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl
Biological ActivityActive isomer of medetomidine (Cat.No. 5160), a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fisher et al (1991) Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur.J.Pharmacol. 192 221. PMID: 1674472.
Scheinin et al (1989) Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635.
Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9. PMID: 2900154.
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Citations are publications that use Tocris products. Selected citations for Dexmedetomidine hydrochloride include:
Garrity et al (2015) Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat. Invest Ophthalmol Vis Sci 38 73. PMID: 25325438.
McAlvin et al (2015) Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. J Inflamm (Lond) 56 3820. PMID: 26066750.
Yuki et al (2011) Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg 112 830. PMID: 21385989.
Do you know of a great paper that uses Dexmedetomidine hydrochloride from Tocris? If so please let us know.
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Selective, high affinity, non-competitive α1A adrenoceptor antagonist
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