NTRC 824

Cat. No. 5438

NTRC 824 C25H26F3N3O6S [1623002-61-8]

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Chemical Name: N-[2-[5-[[(4-Methylphenyl)sulfonyl]amino]-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl]acetyl]-L-leucine

Biological Activity

Potent and selective non-peptide neurotensin (NTS) type-2 receptor antagonist (IC50 = 38 nM). Exhibits >150-fold selectivity for NTS2 over NTS1.

Technical Data

M.Wt:
553.55
Formula:
C25H26F3N3O6S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1623002-61-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Thomas et al (2014) Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-L-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J.Med.Chem. 57 7472. PMID: 25157640.

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Keywords: NTRC 824, supplier, NTRC824, neurotensin, receptors, NTS2, non-peptide, potent, selective, antagonists, Tocris Bioscience, Neurotensin Receptor Antagonist products

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