Cat. No. 5433
Chemical Name: N-(4-Acetylphenyl)-3-(5-ethyl-2-fur
Biological ActivityHECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50 values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mund et al (2014) Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc.Natl.Acad.Sci.U.S.A. 111 16736. PMID: 25385595.
If you know of a relevant reference for Heclin please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Heclin from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Heclin, supplier, E6-AP, carboxyl, terminus, HECT, E3, ubiquitin, ubiquitination, inhibitors, inhibits, inhibts, NAMs, negative, allosteric, modulators, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Negative control for VH 298VH 298
High-affinity inhibitor of VHLcis MZ 1
Negative Control for MZ1MZ 1
(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells.
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.