R 7050

Cat. No. 5432

R 7050 C16H8ClF3N4S [303997-35-5]

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Chemical Name: 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

Biological Activity

Inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.

Technical Data

M.Wt:
380.77
Formula:
C16H8ClF3N4S
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
303997-35-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

King et al (2013) TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci.Lett. 542 92. PMID: 23499961.

Gururaja et al (2007) A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem.Biol. 14 1105. PMID: 17961823.

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Keywords: R 7050, supplier, R7050, tumor, necrosis, TNFa, TNFalpha, TNFα, inhibitors, inhibits, signaling, cytokines, receptors, Tocris Bioscience, Cytokine Receptor products

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