Cat. No. 5432
Chemical Name: 8-Chloro-4-(phenylthio)-1-(trifluor
Biological ActivityInhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
King et al (2013) TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci.Lett. 542 92. PMID: 23499961.
Gururaja et al (2007) A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem.Biol. 14 1105. PMID: 17961823.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses R 7050 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: R 7050, supplier, R7050, tumor, necrosis, TNFa, TNFalpha, TNFα, inhibitors, inhibits, signaling, cytokines, receptors, Tocris Bioscience, Cytokine Receptor products
Find multiple products by catalog number
New Products in this Area
Dual α9β/1α4β1 integrin inhibitor; preferentially mobilizes HSCsATN 161
α5β1 integrin receptor antagonistFSL 1
TLR2/6 agonist (also a putative TLR10 ligand)
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.