Cat. No. 5431
Chemical Name: 2,6-Dihydro-7-[(3-hydroxypropyl)thi
Biological ActivityPotent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wang et al (2014) Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 57 7317. PMID: 25068893.
Murray et al (2005) Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 1 371. PMID: 16370372.
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Keywords: SR 13800, supplier, SR13800, potent, MCT1, inhibitors, inhibits, lactate, uptake, anticancer, antitumour, antitumor, SLC16A1, monocarboxylate, transporters, Tocris Bioscience, Monocarboxylate Transporter Inhibitor products