SR 13800

Cat. No. 5431

SR 13800 C25H29N3O2S [227321-12-2]

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Chemical Name: 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one

Biological Activity

Potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.

Technical Data

M.Wt:
435.58
Formula:
C25H29N3O2S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
227321-12-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Wang et al (2014) Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 57 7317. PMID: 25068893.

Murray et al (2005) Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 1 371. PMID: 16370372.

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Keywords: SR 13800, supplier, SR13800, potent, MCT1, inhibitors, inhibits, lactate, uptake, anticancer, antitumour, antitumor, SLC16A1, monocarboxylate, transporters, Tocris Bioscience, Monocarboxylate Transporter Inhibitor products

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