AS 2444697

Cat. No. 5430

AS 2444697 C19H20N6O4.HCl [1287665-60-4]

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Chemical Name: N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride

Biological Activity

Potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

Technical Data

M.Wt:
432.86
Formula:
C19H20N6O4.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1287665-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chaudhary (2015) Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J.Med.Chem. 58 96. PMID: 25479567.

Kondo et al (2014) Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats. Naunyn Schmiedebergs Arch.Pharmacol. 387 909. PMID: 25052043.

Schmaderer and Heemann (2014) Blocking innate immunity to slow the progression of chronic kidney disease. Naunyn Schmiedebergs Arch.Pharmacol. 387 905. PMID: 25107563.

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Citations are publications that use Tocris products.

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Keywords: AS 2444697, supplier, AS2444697, potent, selective, interleukin-1, receptor-associated, kinase, 4, IRAK4, inhibitors, inhibits, anti-inflammatory, renoprotective, inhibitors, Tocris Bioscience, IRAK Inhibitor products

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