NG 25

Cat. No. 5429

NG 25 C29H30F3N5O2 [1315355-93-1]

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Chemical Name: N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide

Biological Activity

TGF-β-activated kinase (TAK1) inhibitor (IC50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-α and TLR7/8 agonist CL097-stimulated secretion of IFN-β in Gen 2.2 leukemia cells in vitro.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Technical Data

Soluble to 20 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Tan et al (2015) Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J.Med.Chem. 58 183. PMID: 25075558.

Dzamko et al (2012) The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. PLoS ONE 7 e39132. PMID: 22723946.

Pauls et al (2012) Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells. J.Biol.Chem. 287 19216. PMID: 22511786.

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Keywords: NG 25, supplier, NG25, TAK1, TGFbeta, TGFb, TGFβ, activated, kinases, inhibitors, inhibits, MAP4K2, LYN, Abl, Tocris Bioscience, Other Kinase Inhibitor products

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