Cat. No. 5428
Chemical Name: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chloroph
Biological ActivityHigh affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Little et al (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain 138 28. PMID: 25414036.
Tosh et al (2015) Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 11 371. PMID: 26111639.
Tosh et al (2012) Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 55 4847. PMID: 22559880.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses MRS 5698 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MRS 5698, supplier, High, affinity, selective, A3, adenosine, receptors, agonists, antinociceptive, MRS5698, Tocris Bioscience, Adenosine A3 Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
High affinity adenosine A1 receptor antagonistISAM 140
High affinity A2B receptor antagonist
April 10 - 13, 2017