MRS 5698

Cat. No. 5428

MRS 5698 C28H23ClF2N6O3 [1377273-00-1]

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Chemical Name: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide

Biological Activity

High affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.

Technical Data

M.Wt:
564.97
Formula:
C28H23ClF2N6O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
>96 %
Storage:
Store at -20°C
CAS No:
1377273-00-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Little et al (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain 138 28. PMID: 25414036.

Tosh et al (2015) Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 11 371. PMID: 26111639.

Tosh et al (2012) Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 55 4847. PMID: 22559880.

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Keywords: MRS 5698, supplier, High, affinity, selective, A3, adenosine, receptors, agonists, antinociceptive, MRS5698, Tocris Bioscience, Adenosine A3 Receptor Agonist products

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