Cat. No. 5428
Chemical Name: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chloroph
Biological ActivityHigh affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Little et al (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain 138 28. PMID: 25414036.
Tosh et al (2015) Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 11 371. PMID: 26111639.
Tosh et al (2012) Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 55 4847. PMID: 22559880.
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Keywords: MRS 5698, supplier, High, affinity, selective, A3, adenosine, receptors, agonists, antinociceptive, MRS5698, Tocris Bioscience, Adenosine A3 Receptor Agonist products
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