Cat. No. 5425
Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinec
Biological ActivityAquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324. PMID: 23462267.
Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113. PMID: 20924629.
Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411. PMID: 18182301.
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Keywords: TGN 020, supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Tocris Bioscience, Aquaporin Blocker products