TGN 020

Cat. No. 5425

TGN 020 C8H6N4OS [51987-99-6]

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Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide

Biological Activity

Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Technical Data

Soluble to 20 mM in DMSO and to 10 mM in 1eq. HCl with gentle warming
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324. PMID: 23462267.

Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113. PMID: 20924629.

Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411. PMID: 18182301.

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Citations are publications that use Tocris products.

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Keywords: TGN 020, supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Tocris Bioscience, Aquaporin Blocker products

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