TGN 020

Cat. No. 5425

TGN 020 C8H6N4OS [51987-99-6]

Price and Availability

For TGN 020 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide

Biological Activity

Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Technical Data

M.Wt:
206.22
Formula:
C8H6N4OS
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in 1eq. HCl with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
51987-99-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324. PMID: 23462267.

Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113. PMID: 20924629.

Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411. PMID: 18182301.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses TGN 020 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: TGN 020, supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Tocris Bioscience, Aquaporin Blocker products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

Ani 9

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

MONNA

Potent TMEM16A (Anoctamin-1) blocker

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.