Benzbromarone

Cat. No. 5420

Benzbromarone C17H12Br2O3 [3562-84-3]

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Chemical Name: (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)methanone

Biological Activity

TMEM16A/B calcium-activated chloride channel (CaCC) blocker. Inhibits ATP-induced mucin secretion and metacholine-induced airway smooth muscle contraction in vitro.

Technical Data

M.Wt:
424.08
Formula:
C17H12Br2O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
3562-84-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gallos et al (2013) Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am.J.Physiol.Lung Cell Mol.Physiol. 305 625. PMID: 23997176.

Huang et al (2012) Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc.Natl.Acad.Sci.U.S.A. 109 16354. PMID: 22988107.

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Keywords: Benzbromarone, supplier, Benzbromarone, asthma, TMEM16A, TMEM16B, calcium, activated, chloride, channels, blockers, CACC, Tocris Bioscience, Calcium-activated Chloride Channel Blocker products

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