BMH 21

Cat. No. 5417

BMH 21 C21H20N4O2 [896705-16-1]

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Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide

Biological Activity

p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.

Technical Data

M.Wt:
360.41
Formula:
C21H20N4O2
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
896705-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Colis et al (2014) Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J.Med.Chem. 57 4950. PMID: 24847734.

Peltonen et al (2014) A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 13 77. PMID: 24434211.

Peltonen et al (2010) Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS ONE 5 e12996. PMID: 20885994.

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Keywords: BMH 21, supplier, BMH21, p53, pathway, activators, rna, polymerase, inhibitors, inhibits, RPA194, antitumor, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products

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