Cat. No. 5417
Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-1
Biological Activityp53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Colis et al (2014) Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J.Med.Chem. 57 4950. PMID: 24847734.
Peltonen et al (2014) A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 13 77. PMID: 24434211.
Peltonen et al (2010) Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS ONE 5 e12996. PMID: 20885994.
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Keywords: BMH 21, supplier, BMH21, p53, pathway, activators, rna, polymerase, inhibitors, inhibits, RPA194, antitumor, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products