Cat. No. 5414
Chemical Name: N-Methyl-4-nitro-2-(4-(4-trifluorom
Biological ActivityPotent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.
Licensing InformationSold under license from the University of Colorado
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cheng et al (2015) Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv. 1 e1400139. PMID: 26101787.
Cheng et al (2013) Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl. 51 12246. PMID: 22969053.
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Keywords: CU-T12-9, supplier, Potent, TLR1/2, activators, activates, Tocris Bioscience, Toll-like Receptor Agonist products
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