Cat. No. 5414
Chemical Name: N-Methyl-4-nitro-2-(4-(4-trifluorom
Biological ActivityPotent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.
Licensing InformationSold under license from the University of Colorado
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cheng et al (2015) Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv. 1 e1400139. PMID: 26101787.
Cheng et al (2013) Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl. 51 12246. PMID: 22969053.
If you know of a relevant reference for CU-T12-9 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses CU-T12-9 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CU-T12-9, supplier, Potent, TLR1/2, activators, activates, Tocris Bioscience, Toll-like Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Dual α9β/1α4β1 integrin inhibitor; preferentially mobilizes HSCsATN 161
α5β1 integrin receptor antagonistFSL 1
TLR2/6 agonist (also a putative TLR10 ligand)
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.