CU-T12-9

Cat. No. 5414

CU-T12-9 C17H13F3N4O2

Price and Availability

For CU-T12-9 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline

Biological Activity

Potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.

Licensing Information

Sold under license from the University of Colorado

Technical Data

M.Wt:
362.31
Formula:
C17H13F3N4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cheng et al (2015) Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv. 1 e1400139. PMID: 26101787.

Cheng et al (2013) Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl. 51 12246. PMID: 22969053.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses CU-T12-9 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CU-T12-9, supplier, Potent, TLR1/2, activators, activates, Tocris Bioscience, Toll-like Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

Toll-like Receptor Pathway

Toll-like Receptor Signaling Pathway

Toll-like receptors are important in the inflammatory and adaptive and innate immune responses against threatening microbes. View pathway or download PDF today.

divider line

New Products in this Area

ATN 161

α5β1 integrin receptor antagonist

FSL 1

TLR2/6 agonist (also a putative TLR10 ligand)

Cilengitide

Potent and selective inhibitor of integrins αvβ3 and αvβ5

SM 324405

Potent TLR7 agonist

RS 09

TLR4 peptide agonist; acts as an adjuvant in vivo

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ASCB 2016

ASCB 2016

December 3 - 7, 2016

San Francisco, CA,

Booth: 314