Cat. No. 5410
Chemical Name: 3-[7-(Trifluoromethyl)-5-[2-(triflu
Biological ActivityPotent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Parks et al (2011) Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J.Med.Chem. 54 233. PMID: 21128593.
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Keywords: TC-I 2014, supplier, TC-I2014, TRPM8, antagonist, Tocris Bioscience, TRPM Antagonist products