Cat. No. 5410
Chemical Name: 3-[7-(Trifluoromethyl)-5-[2-(triflu
Biological ActivityPotent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Parks et al (2011) Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J.Med.Chem. 54 233. PMID: 21128593.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TC-I 2014 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TC-I 2014, supplier, TC-I2014, TRPM8, antagonist, Tocris Bioscience, TRPM Antagonist products
Find multiple products by catalog number
New Products in this Area
Selective TRPM8 blockerM 084 hydrochloride
TRPC4/5 channel blocker; antidepressant and anxiolyticA 425619
Potent TRPV1 antagonistRN 9893 hydrochloride
Potent and selective TRPV4 antagonist
December 13 - 15, 2016