Cat. No. 5408

Ispinesib C30H33ClN4O2 [336113-53-2]

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Alternative Name: SB 715992

Chemical Name: N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide

Biological Activity

High affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app = 1.7 nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro. Induces tumor regression of breast cancer cell xenografts in mice.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Purcell et al (2010) Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin.Cancer Res. 16 566. PMID: 20068098.

Lad et al (2008) Mechanism of inhibition of human KSP by ispinesib. Biochemistry 47 3576. PMID: 18290633.

Davis et al (2006) Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer 6 22. PMID: 16433906.

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Keywords: Ispinesib, supplier, SB715992, CK0238273, high, affinity, selective, potent, allosteric, kinesin, spindle, protein, KSP, hsEG5, Tocris Bioscience, Kinesin Inhibitor products

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