Cat. No. 5408
Alternative Name: SB 715992
Chemical Name: N-(3-Aminopropyl)-N-[(1R)-1-[7-chlo
Biological ActivityHigh affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app = 1.7 nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro. Induces tumor regression of breast cancer cell xenografts in mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Purcell et al (2010) Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin.Cancer Res. 16 566. PMID: 20068098.
Lad et al (2008) Mechanism of inhibition of human KSP by ispinesib. Biochemistry 47 3576. PMID: 18290633.
Davis et al (2006) Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer 6 22. PMID: 16433906.
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Keywords: Ispinesib, supplier, SB715992, CK0238273, high, affinity, selective, potent, allosteric, kinesin, spindle, protein, KSP, hsEG5, Tocris Bioscience, Kinesin Inhibitor products
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