ONO 8130

Cat. No. 5406

ONO 8130 C25H28N2O5S2 [459841-96-4]

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Chemical Name: 4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid

Biological Activity

EP1 receptor antagonist. Exhibits analgesic effect in a mouse mode of cystitis. Orally bioavailable.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Miki et al (2011) ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 152 1373. PMID: 21396778.

Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. Psychopharmacology 179 54. PMID: 15759151.

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Keywords: ONO 8130, supplier, ONO8130, EP1, receptor, antagonists, antagonism, analgesics, cystitis, Tocris Bioscience, Prostanoid Receptor Antagonist products

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