Cat. No. 5406
Chemical Name: 4-[[[2,3-Dihydro-6-[(2-methylpropyl
Biological ActivityEP1 receptor antagonist. Exhibits analgesic effect in a mouse mode of cystitis. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Miki et al (2011) ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 152 1373. PMID: 21396778.
Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. Psychopharmacology 179 54. PMID: 15759151.
If you know of a relevant reference for ONO 8130 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses ONO 8130 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ONO 8130, supplier, ONO8130, EP1, receptor, antagonists, antagonism, analgesics, cystitis, Tocris Bioscience, Prostanoid Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Highly potent P2Y12 antagonistFTY 720
Potent S1P receptor agonist; also immunosuppressantCinacalcet hydrochloride
Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailableAMG 837 hemicalcium salt
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligandAZD 1283
High affinity P2Y12 antagonistEx 26
Potent and selective S1P1 receptor antagonist
June 14 - 17, 2017
Boston, MA, USA