Cat. No. 5406
Chemical Name: 4-[[[2,3-Dihydro-6-[(2-methylpropyl
Biological ActivityEP1 receptor antagonist. Exhibits analgesic effect in a mouse mode of cystitis. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Miki et al (2011) ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 152 1373. PMID: 21396778.
Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. Psychopharmacology 179 54. PMID: 15759151.
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Keywords: ONO 8130, supplier, ONO8130, EP1, receptor, antagonists, antagonism, analgesics, cystitis, Tocris Bioscience, Prostanoid Receptor Antagonist products
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