Cat. No. 5402

6bK C41H55N7O7 [1774353-12-6]

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Chemical Name: (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide

Biological Activity

Insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

Licensing Information

Sold for research purpose under license from Harvard University

Technical Data

Soluble to 1 mg/ml in water
>97 %
Store at -20°C


Other Information

  • This compound is supplied in net weight as the TFA salt.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Maianti et al (2014) Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94. PMID: 24847884.

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Keywords: 6bK, supplier, Insulin, degrading, enzymes, IDE, inhibitors, inhibits, glucagon, amylin, glucose, tolerance, diabetic, diabetes, Tocris Bioscience, Insulin and Insulin-like Receptors products

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