6bK

Cat. No. 5402

6bK C41H55N7O7 [1774353-12-6]

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Chemical Name: (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide

Biological Activity

Insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

Licensing Information

Sold for research purpose under license from Harvard University

Technical Data

M.Wt:
757.92
Formula:
C41H55N7O7
Solubility:
Soluble to 1 mg/ml in water
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
1774353-12-6

Resources

Other Information

  • This compound is supplied in net weight as the TFA salt.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Maianti et al (2014) Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94. PMID: 24847884.

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: 6bK, supplier, Insulin, degrading, enzymes, IDE, inhibitors, inhibits, glucagon, amylin, glucose, tolerance, diabetic, diabetes, Tocris Bioscience, Insulin and Insulin-like Receptor products

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